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Methods Lipopolysaccharide-stimulated primary rat fibroblast-like synoviocytes (FLS) were treated with an AMP-activated protein kinase (AMPK) inhibitor or siRNA and carnitine palmitoyltransferase 1 (CPT1) siRNA to examine the synovial protective effects of l-carnitine

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These results imply that if dephosphorylation could be controlled, PKC down-regulation could be fine-tuned

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[PMC free article: PMC3697085] [PubMed: 22102062] 457

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