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0.5 mg/0.1 mL saline/each eye) in a 4-week study permits a very simple and effective protocol, fundoscopy, behavior presentation, tonometry, and histology, to show timely progression of rapid retinal ischemia in rats [13]

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However, their clinical benefits remain modest and variable, and their use is associated with safety concerns such as amyloid-related imaging abnormalities (ARIA), costly treatment, and invasive administration routes

That the agency is investing public resources to review a compound whose own advocates withdrew their endorsement underscores the difficulty of the regulatory position these peptides occupy

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Furthermore, the depletion of glucocorticoids, through removal of the adrenal gland, resulted in an increase in adult hippocampal neurogenesis and removed stress-induced suppression of cell proliferation in the hippocampus [145]