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Emerging drug profile: Krebs cycle and cancer: IDH mutations and therapeutic implications

doi: 10.1148/rycan.240312

It also helps with protecting cells, fertility, and brain health

The diagnostic process typically involves: Clinical history taking, focusing on symptoms (fatigue, neurological changes, dietary habits) Physical examination for signs of anaemia or neurological impairment Blood tests including full blood count, serum B12, and often folate levels Additional investigations such as intrinsic factor antibodies or parietal cell antibodies if pernicious anaemia is suspected For borderline results, additional tests like holotranscobalamin (active B12) may be considered NICE guidance recommends that treatment should commence based on clinical presentation if neurological symptoms are present, without waiting for laboratory confirmation, as delays can result in irreversible nerve damage

doi: 10.1152/ajpgi.00024.2012 24

Effects of supraphysiological doses of levothyroxine on sleep in healthy subjects: a prospective polysomnography study