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NAD+ (nicotinamide adenine dinucleotide) is a coenzyme critical to cellular energy production and DNA repair

Oral clonidine, oral carvedilol, and Botox injection have the same effect, so they are off-label alternatives

102 PolitisA.OlgiatiP.MalitasP.AlbaniD.SignoriniA.PolitoL.et al (2010)

A common reason for incomplete improvement is that treatment focuses only on suppressing nerve pain, without identifying what is maintaining that sensitivity over time