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Another model to assess the relative importance of endocrine versus paracrine/autocrine IGF-I is the liver-specific Ghr ko mouse

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[6] This mechanism of action underlies its clinical uses: it induces ovulation in women who need assistance conceiving, and it stimulates testosterone production in men who have functional testes but inadequate pituitary stimulation

Where applicable, teams can also align language with official method documentation used in their own labs