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When -catenin is instead stabilized to increase canonical Wnt signaling activity, otic ectoderm expands at the expense of epibranchial cells (Ohyama et al., 2006)

Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial

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once every 3 weeks for 3 months) solution is well tolerated in rats at doses up to 200 mg/kg with no life-threatening toxicity, and the STD 10 is greater than 200 mg/kg [2]