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6 a , TSA (1 M), the strongest HDAC inhibitor, completely inhibited HDAC activities, and Buty, the relatively weak HDAC inhibitor, dramatically inhibited HDAC activity at low HDAC concentration (1 g protein) but with the increase of HDAC donor (5, 30 g protein), the inhibiting effect of Buty (1 mM) on HDAC activity gradually declined