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The study found that serum B12 levels were comparable, and in some cases higher, among those using the sublingual supplement (1)

Important limitation: Neither is FDA-approved, and human clinical data relies heavily on animal models and observational reports

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31 Since the 2021 review, one more RCT has been published that compared oral B12 alone, 25 g per day (form not reported), or with folate (800 g per day) versus no supplements for 6 months in patients with mild cognitive impairment

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Receiving this form of injection provides a direct and efficient way to boost B12 levels in the body, bypassing potential absorption issues in the digestive system