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The mechanism of action of cisplatin (and carboplatin) involves covalent binding to purine DNA bases, which primarily leads to cellular apoptosis

J Am Chem Soc (2014) 136:45516

Modern nutritition in health and disease

Thus, the general principle of the selenenylsulfide sensing in the non-reduced TrxR1 is the process of opening selenenylsulfide bond in response to the oxidizing reagents with a highly electrophilic active species

WADA prohibits r compounds based on meeting two of the three criteria: potential to enhance performance

For metabolite assignments, two-dimensional NMR spectra including 1 H 1 H COSY, 1 H 1 H TOCSY, 1 H J -resolved, 1 H 13 C HSQC and 1 H 13 C HMBC for typical samples were acquired and processed as described previously [49]