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10.1016/j.ejphar.2015.12.016 36 KolovratM.GojkovicS.KrezicI.MalekinusicD.VrdoljakB.Kasnik KovacK

J Biol Chem (2004) 279(49):5153440

HIF-1-dependent BNIP3 expression was proven to induce mitophagy in prolonged hypoxia [53]

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(2011) further identified that NLRP3 inflammasome activation was a driver of disease progression through amplification of initial inflammatory cascades

Some clinics pivoted to recommending FDA-approved alternatives for weight management, including GLP-1 receptor agonists such as semaglutide (Wegovy) and tirzepatide (Zepbound), both of which have extensive Phase III data and FDA-approved labels