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N-acetylcysteine (NAC), a glutathione precursor, reportedly acts as an anti-oxidant factor by targeting ROS 30 , and anti-oxidant effects of NAC in animal models exhibiting pathologies associated with ROS have been reported 31,32,33

The MCT diet generates a higher level of ketone bodies during hepatic fat metabolism compared to the LCT diet [16]

ADP, adenosine diphosphate

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doi: 10.1186/s12967-024-05171-1 45 HajdusianekW.ZorawikA.Waliszewska-ProsolM.PorebaR.GacP

Thus, roGFP2 oxidation by PfGrx occurs preferentially via a glutathione-dependent monothiol and not a glutathione-independent dithiol mechanism (Fig