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Jastrzb R, Graczyk D, Siedlecki P

doi: 10.1038/ki.2014.128 106 AlicicRZJohnsonEJTuttleKR

It is intriguing that genetic suppression in a yeast model of the disease has also been reported, where deletion 26 or missense mutations on the regulatory domain 25 can overcome the deleterious effects of some HCU mutations

Selected adults may increase to 7.2 mg after at least four weeks at 2.4 mg when additional weight reduction is clinically indicated. The 0.25 mg dose is the starter rather than the maintenance target