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Rejeeth C, Varukattu NB, Sharma A, Kumar RS, Almansour AI, Arumugam N (2023) A novel azathioprine polysaccharide nanoparticle enhances the efficacy of systemic lupus erythematosus therapy

Once preliminary evidence suggests one therapy is better, randomization may be considered unethical

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See: References 1 Ladich E, Butany J, Virmani R

Apart from phagocytosis of extravasated RBCs, it is suggested that CD36 may participate in scavenging several lipoproteins, including high-, low-, and very low-density lipoproteins (HDL, LDL, and VLDL), oxidized LDL, long-chain fatty acids (LCFA), or advanced glycation end products (AGEs) [98,99,100]

Additionally, activated ERK is responsible for initiating a negative feedback loop at various levels of the MAPK pathway to regulate its activity