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In addition, in an attempt to explain why removing these plaques does not result in improvements in cognition and mood and why cognitions and moods in these individuals have ebbs and flows, we postulate that it is not the plaques that cause the cognitive symptoms but, rather, inflammation in the brain resulting from the immune system's response to pathogens

Accordingly, molecules with a good affinity and selectivity for these receptors/transporters can be explored as brain-targeting agents

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Testing the affinity of the ligand to the target molecule may be a necessary initial step before purification since extremely low or high affinity can significantly reduce yield

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