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Somatic symptoms, including hot flashes, night sweats, palpitations, headaches and musculoskeletal pain, are also common and can create a bidirectional feedback loop with mood disturbances, exacerbating both psychological and physical symptoms

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The integrated regulation of insulin secretion in pancreatic -cells provides an opportunity to develop quantitative data-based computer models relating metabolic sensing to electrophysiological events and to intracellular Ca 2+ dynamics, ultimately leading to exocytosis of the secretory granules

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J., Guan, Y

The practical consequence: if oral bioavailability is 20%, a 50 mg oral dose delivers the same systemic exposure as a 10 mg subcutaneous dose