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of India, New Delhi (BT/PR32697/MED/29/1471/2019), Institution of Eminence, University of Delhi (IoE-DU/MRP/2022/056) and ICMR-DHR (R.12013/13/2023-HR) for the work contributed and elaborated in this review

In patients with ME/CFS, Long COVID, and fibromyalgia, clinical studies consistently reveal a state of gut dysbiosis, characterized by a depletion of beneficial, anti-inflammatory bacteria and an overgrowth of pro-inflammatory strains

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Buffers like citrate, phosphate, and acetate are used to adjust pH and optimize stability

Although promising, gene therapy still faces key challenges, including vector immunogenicity, achieving precise tissue-specific expression regulation, safety assessment of long-term expression, and controllability of expression intensity (Jakabek et al., 2025)

Note that sites that generate ROS in mitochondria produce a mixture of O2 and H2O2, but the latter form dominates over the former