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Its not recommended due to lack of long-term safety data

Reduced physical activity often accompanies the initial weeks of GLP-1 therapy when gastrointestinal symptoms are most prominent

Cytochrome c lysine acetylation regulates cellular respiration and cell death in ischemic skeletal muscle

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This leads to a persistent state of heightened inflammation within the intestinal mucosa and impairs the functionality of goblet cells and mucosal epithelial regeneration, thereby compromising the repair process of the damaged intestinal barrier (Jiang et al., 2010)