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Microbiol Mol Biol Rev 72, 471494

Importantly, hyperpolarized -[1- 13 C]gluconolactone metabolism to [1- 13 C]6PG serves to differentiate tumor from normal brain and to report on response to TMZ in rats bearing orthotopic tumor xenografts in vivo

177 Both in vitro and in vivo studies have demonstrated that epacadostat can reduce tumor growth and promote the proliferation of T cells and NK cells