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Acknowledgements We are highly thankful to the Director of ICAR-Central Soil Salinity Research Institute, Karnal and Head, Central Soil Salinity Research Institute, Regional Research Station, Lucknow, Uttar Pradesh, India for their constant encouragement, motivation, and help in writing this review.

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The median progression-free (PF) and overall survival (OS) rates were 12.5 months and nearly 30 months respectively, but these outcomes did not reach statistical significance, and the study was not sufficiently powered for efficacy endpoints