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The thiol-disulfide equilibrium within the cell is known to regulate a diverse number of metabolic processes including enzyme activity, transport activity, signal transduction, and gene expression via alteration of redox sensitive transcription factors such as activator protein-1 (AP-1), nuclear factor kappa B (NFB) and p53 (Hutter et al., 1997

This observation aligns with our hypothesis that the mechanisms governing lifespan extension vary considerably depending on the type of longevity interventions

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Modification role of dietary antioxidants in the association of high red meat intake and lung cancer risk: evidence from a cancer screening trial