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mtDNA variants have been shown to regulate methylation profiles and the transcription of genes related to inflammation and angiogenesis, particularly the expression of VEGF

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Graphical Abstract Highlights Electrospun HAGSHPVA nanofiber scaffolds were successfully fabricated, forming uniform, bead-free fibers (~ 100 nm) with excellent structural integrity confirmed by SEM and TEM

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The initial management strategy for patients who present with chronic HS lesions is the administration of antibiotics including doxycycline 100 mg twice daily, tetracycline 500 mg twice daily, and lymecycline 300 mg twice daily (these doses were administered in a prospective study in HS patients, with a mean duration of treatment of 4.3 months) (45), or combinations including rifampicin 300 mg twice daily plus clindamycin 300 mg twice daily, for 10 to 12 weeks (19, 46)