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The criteria for selecting differentially expressed genes (DEGs) were set as p [mean(|logFC|) + 2sd(|logFC|)] 33

A site-directed mutagenesis study showed that hydrogen bonding of R1433 and Y1349 in the C -terminus is required for hTRPM2 activation induced by the C -terminal binding of ADPR (Fliegert et al., 2017b)