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S., Collard, H

It's due to our lifestyle behaviors, y'all know

The first enzyme is feedback inhibited by high levels of glutathione

This phenomenon may be attributed to the pro-oxidative nature of the predominant AhR ligands in these contexts, including oxyindole, IS, TCDD and dioxins

CHAC1 is often induced under cellular stress, including unfolded protein response signaling, and its activation modulates redox balance and influences apoptosis and ferroptosis 30

Especially during the differentiation of esophageal squamous epithelium, BMP-driven ROS production activates Nrf2-mediated oxidative stress response, a mechanism crucial for normal epithelial differentiation [122]