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Compound binding to tissue components, e.g., melanin, is one mechanism by which drug retention and/or accumulation can occur

, Rodriguez, F., Recchia, D., Degiacomi, G., Pasca, M.R., Maveyraud, L

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Changes in iron metabolism significantly impact the regulation of various immune cells in the tumor microenvironment, particularly natural killer (NK) cells, T cells, macrophages, neutrophils, and various immune factors (Figure 4)