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This is the first study to report mature-onset obesity in mice lacking a functional IL-6 gene

The in vitro experiment also revealed acrolein adduction to Arg-307, forming six-membered heterocycle

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Another culture model was employed by Leng et al

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4.3 Theoretical mechanism for the selenenylsulfide to attack the S-S bond of DTNB or the S-N bond of GSNO Our observations can be rationalized by understanding the type of bonds that participate in reactions with selenenylsulfide bond (S-Se bond), which becomes highly polarized (R2 in Figure 3) under our experimental conditions at pH 7.5