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The Y1003 site, located in the juxtamembrane domain, is a negative regulatory site for c-MET signaling that acts by recruiting c-CBL (casitas B-lineage lymphoma) [Petrelli et al

Proceedings of the National Academy of Sciences, 111(36): 1301013015, September 2014

Microbiota-derived LPS and peptidoglycans (PGN) were demonstrated to cross the gut barrier and activate their respective receptors, TLR4 and TLR2 in peripheral blood mononuclear cells

[DOI] [PubMed] [Google Scholar] 4.Ballatori N, Krance SM, Notenboom S, Shi S, Tieu K, Hammond CL

For researchers concerned about the muscle wasting associated with GLP-1 medications, this mechanism is highly relevant

PubMed Fletcher, M.M., Halls, M.L., Christopoulos, A., Sexton, P.M., & Wootten, D