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The antibody itself must also be optimized: it should bind strongly to the target and internalize efficiently, and it should be engineered (often humanized or fully human) to avoid immune rejection by the patient

LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function

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once absorbed and inside the cells it is removed, thus leaving the glutathione molecule intact

Injection Frequency Weekly or split into 2x/week (e.g., 60mg Monday, 60mg Thursday for a 120mg/week protocol)

Eur J Pharm Biopharmaceutics: Off J Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik eV