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Description

However, no clear pattern was found across treatment days

Although tools such as DdCBE and TALED achieve mitochondrial localization through mitochondria-targeting sequences, accumulating evidence indicates that they can nonetheless induce detectable off-target edits in nuclear DNA [548, 549]

Methods: De- identified publicly available population data from the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research database was evaluated