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10.1053/j.gastro.2014.02.009 26

Interestingly, these remaining 6 DUSPs are atypical DUSPs lacking the KIM

, H 2 alleviates IVDD by restoring mitochondrial homeostasis: it suppresses excessive mitochondrial death responses (mitochondrial unfolded protein response and unselective mitophagy) while enhancing 5-monophosphate-activated protein kinase-mediated mitochondrial biogenesis and controlled mitophagy ( Figure 2A and B )

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R.ArifM.ArifF.AroraN.et al (2017)

In ROXY9, increasing oxidative conditions led to the formation of a disulfide between Cys21 and Cys24 of the C 21 CLC 24 signature with midpoint redox potentials at around 230 mV at p H 7.0, independent of whether DTT/dithiane or GSH/GSSG was used