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Briefly, the objective of the estimand framework is to align the clinical trial objectives with the study design, endpoints and analysis, in order to improve study planning and the interpretation of study results (26)

Restless leg syndrome, characterized by an irresistible urge to move the legs during rest accompanied by unpleasant sensations, affects 26.155.0% of cirrhosis patients, further disrupting sleep

However, Kwak et al

Excess glutamate accumulates extracellularly during stroke, causing excessive NMDAR activation and neuroexcitotoxicity, as well as inducing NMDAR-mediated iron uptake (Cheah et al., 2006), as BBB dysfunction during stroke allows iron-containing substances to enter the brain and accumulate in areas of ischaemic brain tissue prior to neurodegeneration (Helal, 2008

Inhibition of apoptosis protects mice from ethanol-mediated acceleration of early markers of CCl4-induced fibrosis but not steatosis or inflammation

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