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The body cannot produce B12 naturally, so it must be obtained through diet (primarily animal products) or supplementation

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"Effect of chronic ranitidine treatment on secretion of intrinsic factor"

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This is partly a result of insulins effects on hepatic GHR expression, and partly a post-receptor signaling effect as unraveled by extensive animal studies (reviewed in (60)

Complete rest from aggravating activities for at least the first 2 to 4 weeks of treatment allows the enhanced healing response to gain traction before gradually reintroducing load