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In the control group, the normal large intestine was in the reduced state, but when colitis was induced, it shifted toward the oxidized state due to inflammation (Fig

As far as the conversion of glutamate to ketoglutarate goes, this reaction can be catalyzed either by glutamate dehydrogenase (GDH), which releases free ammonia, or by a family of aminotransferases, which transfer the amine to ketoacids, expanding the nonessential amino acid pool