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Cell proliferation pathways such as PI3K/AKT/mTOR and NF-B can further enhance anti-apoptotic systems, promoting tumor cell resistance to apoptosis

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Targeting pro-survival and non-apoptotic death pathways is essential to combat cancer and chemoresistance, as impaired apoptosis plays a role in both conditions

Furthermore, CAF-derived exosomes, which carry acetic acid, lipids, amino acids, or TCA intermediates, are taken up by pancreatic cancer cells via macropinocytosis and are associated with the inhibition of mitochondrial oxidative phosphorylation and increased compensation of glycolysis

This exercise-induced increase in GSH within muscle fibers is likely due to increased activity of a key enzyme involved in GSH synthesis (190)

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