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Researchers commonly study one single-agonist and one multi-agonist side-by-side in the same experiment

a high-cardiovascular-risk kidney cohort showed a slower decline in kidney function and about a third less protein leak, which travels to a similar-risk body, not a healthy one. Lean and metabolically healthy: a safety read, not an efficacy target No long trial has tested tirzepatide in lean, metabolically healthy people

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Special Point: Several classes of medications can decrease the bodys ability to absorb vitamin B12

The challenge historically has been that pure glucagon agonism worsens glycemia

Its a mechanical issue, but with profound biological consequences