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Missing metabolite values were imputed by replacement with half the minimum value for each metabolite in all samples

This process reduces endothelial junction protein expression, thereby mitigating albumin leakage from endothelial cells and reducing white blood cell infiltration after I/R, which alleviates cellular edema and enhances coronary vascular endothelial barrier integrity, as well as minimizing microvascular leakage (He et al., 2022)