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Epithelia are tight tissues due exclusively to the presence of TJ that selectively regulate the paracellular flux of ions (see Role of Tight Junctions in Crucial Physiological Processes)

Livadas S, Bothou C, Androulakis I, Boniakos A, Angelopoulos N, Duntas L

PubMed Shadiack, A.M., Sharma, S.D., Earle, D.C., Spana, C., & Hallam, T.J

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Together, these findings underscore that the cGASSTING pathway is not only a molecular sentinel for pathogen detection but also a critical driver linking mitochondrial stress and mtDNA release to chronic neuroinflammation in NDDs