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Barratt RW, Johnson GB, Ogata WN

Increased accumulation and uncontrolled mitochondrial ROS generation can harm mitochondrial components, including proteins, membranes, and mtDNA, and induce mitochondrial quality control (MQC) [125,126,127]

Inactivation of A2AR reshapes activated CD8 + T cell metabolism toward GSSG accumulation

Moreover, iron promoted IL-6 levels in CD11c + cells, thereby increasing the hepatic infiltration of neutrophils and promoting the inflammatory responses

The nuclear isoform was also up-regulated by DHA, but its absolute magnitude was negligible compared to m/c- Gpx4 (Figure 2)

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