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Downstream of HIFiron remodeling, ferroptosis in intestinal epithelial cells (IECs) constitutes a key mechanism that converts upstream threshold shifts into epithelial barrier failure and inflammatory amplification in IBD

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The mammalian genome encodes 18 HDACs, which are grouped into four classes: Class I HDACs (HDAC1, 2, 3, and 8) are primarily nuclear

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