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For the kidney, degeneration of glomerular structure and dilatation of Bowmans space, degeneration of proximal and distal tubule, vascular congestion and inflammatory cell infiltration were taken into consideration

doi: 10.1002/bem.20656 141

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But since the 60 mg format enables longer continuous use, understanding the side effect timeline is especially relevant

Existing data instead indicate generally low colonization stability even for well-studied probiotic strains: for example, Escherichia coli Nissle 1917 does not persist long-term in the human gut following oral administration (Charbonneau et al., 2020)

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