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Description

H.SharmaN.TranN

22 CAT mRNA level and its activity are usually upregulated when there is a disturbance in the oxidative status, particularly in H 2 O 2 levels

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These observations also imply that nutrient supply, including dietary methionine or cysteine, could add to patient-to-patient variability in response to therapy targeting the MAT2A/PRMT5/MTAP axis and that combining MAT2A/PRMT5 inhibition with nutrient depletion could result in enhanced responses