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Although their protective role in cardiovascular and neurological diseases is clear, their role in cancer remains controversial: Different PRDX isoforms may have a tumor-suppressor or an oncogenic role, depending on the cancer type

After sonication (2 pulses of 5 s at 4 C), the cell debris was separated by centrifugation at 1000 g for 10 min, and the supernatant was ultracentrifuged at 80,000 g for 30 min at 4 C

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Ethics approval and consent to participate The mouse studies were performed following the guidelines approved by the Institutional Animal Care and Use Committees at MD Anderson Cancer Center