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6 Both pathways highlight ROS as key initiators of NETosis

26 Nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase, xanthine oxidase, nitric oxide synthase (NOS), lipoxygenase, and mitochondrial enzymes generate O 2

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GajdosechovaZMesterZFeldmannJKruppEM.The role of selenium in mercury toxicity Current analytical techniques and future trends in analysis of selenium and mercury interactions in biological matrices

2006 Feb;27(2):240-4

However, while some animal studies suggest that EAAT2 downregulation occurs prior to motor neuron loss, others are compatible with the hypothesis that the downregulation of EAAT2, the astroglial expression of which depends on the presence of neurons (Morel et al., 2013), is a consequence of neuronal degeneration