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Schwab MA, Sauer SW, Okun JG, Nijtmans LG, Rodenburg RJ, van den Heuvel LP et al

If you experience severe or prolonged pain, consult with your healthcare provider for proper care and support

Since it's water-soluble, your body simply flushes out what it doesn't need through your urine

Br J Pharmacol (2011) 164(4):1079106

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This effect does not correlate with changes in mRNA levels in GHRH neurons in the ARC