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doi:10.3109/00016480902882469 Agostini F, Mangone M, Santilli V, et al

In addition to the systemic differences between rodents and humans, several mechanistic constraints further reduce the likelihood that GLP-1secreting engineered probiotics will succeed clinically

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This mechanistic complementarity is the basis for the rumor of the Wolverine combo, although no peer-reviewed study has yet validated the combo itself