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J Proteome Res 15:38833895

Glutathione also plays a role in detoxification by binding to heavy metals in the liver

In monocrotaline-induced PH models, PAECs exhibit LPO accumulation, GPX4/FTH1 downregulation, and NADPH oxidase 4 (NOX4) upregulation, resulting in HMGB1 release

Past studies across different MnSOD isoforms have established that subtle changes in hydrogen bonding and residue orientation lead to significant changes in catalysis, mainly due to shifts of the net electrostatic vectors 35,37,64,78,79