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When joint discomfort occurs after starting B12, it is typically coincidental or related to other factors such as excipients in formulations, injection-site effects, pre-existing musculoskeletal conditions, or rare hypersensitivity reactions rather than a direct effect of the vitamin itself

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Intriguingly, when 5-amino-1MQ treatment was added to the training routine, daily distances run not only increased but tapered off to a much lesser extent than that seen with exercise training alone