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Synergy was defined when the measured leukemia cell viability upon combination of the drugs (blue curve) was lower than what was predicted based on additive effects between the drugs (black Bliss Prediction curve)

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Cellular decision making and biological noise: From microbes to mammals

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Both express CSC markers (CD133, SOX2, nestin) and show intrinsic resistance to cisplatin and etoposide due to upregulated ABC transporters (e.g., ABCG2) and anti-apoptotic proteins (e.g., BCL2) (78, 86, 8891)