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When the intracellular Ca 2+ concentration spikes, EF hands bind with these calcium ions, and the kinase domain remains free, activating the target phosphorylation (Harmon et al., 1994

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10 658663 10.1016/j.cbpa.2006.09.020 [DOI] [PubMed] [Google Scholar] Zhou P., Lugovskoy A

The GSH redox cycle is a major source of protection against mild oxidative stress with the GPx, antioxidant enzyme that oxidizes GSH to GSSG to protect cells against the proliferation of reactive oxygen species (ROS) or reactive nitrogen species (RNS), sparing them from oxidative damage, while catalase is becoming increasingly important in protecting against severe oxidative stress [3, 6, 10]