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IDD can lead to many related and often progressive medical conditions as a result of spinal instability, disc herniation, and nerve impingement such as spondylosis, which refers to degenerative and osteoarthritic changes to the discs and vertebral bones, and sciatica, where pressure put on the sciatic nerve root by a herniated disc or bone spur can cause discomfort, pain, and limb weakness (Mulleman et al., 2006

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Remarkably, TILs from 11 of 28 (39%) analyzed epithelial tumors with the 8 most frequent p53 mutants responded when co-cultured with DC pulsed with autologous mutated p53 epitopes