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Cell Death Dis 14 , 648 (2023)

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10.4049/jimmunol.151.7.3853 16 BroekJ

17 More than 40 drug substrates have since been identified for the GI microbiota, 5,1821 highlighting the ability of gut microbes to perform diverse chemical transformations on drugs, including reduction, hydrolysis, the removal of a succinate group, dehydroxylation, acetylation, deacetylation, the cleavage of a N-oxide bounds, proteolysis, denitration, deconjugation, thiazole ring opening, deglycosylation and demethylation

Recent studies have also shown that the inflammatory response of macrophages can be attenuated by inhibiting succinic acid (63, 64)